Zanaflex: An Effective Muscle Relaxant

About Zanaflex: Zanaflex is an adrenergic agonist drug which is used primarily in the treatment of spasticity and certain partial paralysis cases. This drug works as a muscle relaxant and prevents the sensation of pain in these cases.

Trizanidine is the actual drug although there are many other trade names including Zanaflex. This drug works centrally as an adrenergic agonist.

It is also used for the treatment of spasms, cramping and various other muscle issues. The chemical formula of Zanaflex is C9H8ClN5S.

This drug is available in the consumer market as oral tablets. Even in severe issues of the CNS (Central Nervous System) or the spinal cord, this is used for pain treatment and for muscle relaxation with severe problems of the CNS (Central Nervous System) and spinal cord.

Although it is not officially recommended by medical science and doctors, Zanaflex is sometimes used in the case of migraine pain and even as an aid for sleeping.

How Zanaflex Works: Zanaflex is a known compound, which is derived from Imidazole. In cases of spasticity, partial paralysis and other related spinal injuries, some excitatory amino acids are released.

These amino acids are generally released in the spinal neurons. Zanaflex works by inhibiting the release of these amino acids. This drug also helps in the enhanced activity of glycine, thus helpsingin muscle relaxation.

Zanaflex also aids in the enhancing action of the vibratory inhibition in case of H-reflex. Co-contraction, especially of abnormal types, can lead to spasticity.

This drug aids in decreasing these abnormal co-contractions, and thus works as an anti-spasticity drug. However, Zanaflex can also have side effects on patients affected by hypertension.

Since this drug works directly on the central nervous system, the drug should be avoided if it is found to be dangerous to the individual.

How To Take Zanaflex: In case of multiple sclerosis and spasticity, Zanaflex is usually administered as 4 mg oral tablets once a day.

The dosage may be increased, if necessary, in order to increase the efficacy of the drug. The dosage can be given as 3 times daily for the next 24 hours, if needed.

The dose can then be increased up to 2 mg if needed for the next 4 days to one week. In case of muscle spasms, Zanaflex can be administered as 2 mg oral tablets once a day.

In this case, the dose of Zanaflex can also be increased, if needed, to increase the effectiveness.

Precautions And Side Effects Of Zanaflex: Zanaflex has 281 major and 596 moderate drug interactions. The drugs with which Zanaflex has major interactions include Caffeine, Quinapril, Acebutolol, Isometheptene Mucate, Salicylamide, Phenylephrine, Famotidine, Methyldopa, Norethindrone, Ambrisentan, Anagrelide, Amyl nitrite, etc.

The drugs with which this drug shows moderate interactions include hydrocodone, hyoscyamine, pyrilamine, fentanyl, scopolamine, guaifenesin, pseudoephedrine, chlorpheniramine, dextromethorphan, pentazocine, and acetylcarbromal.

Zanaflex has interaction with four medical conditions including liver toxicity, hypo and hypertension and in some cases, renal malfunction and sometimes psychoses.

In order to avoid these interactions, the doctor must be informed clearly about the medical history of the patient.

The general side effects of Zanaflex include

  • drowsiness,
  • weakness,
  • dizziness,
  • vomiting,
  • diarrhea etc.

Zanaflex might also have some allergic reactions in afew cases.

The allergic symptoms include

  • extreme rash,
  • hives,
  • tiredness,
  • breathlessness,
  • swelling in the mouth region,
  • yellowing of the skin,
  • inability to control bladder movements.

In the case of a Zanaflex overdose, the doctor should be contacted immediately. The dosage of this drug should be increased only if advised by the doctor.

The dose of the medication should not be stopped without the doctor’s consent.